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John Griffiths (Training)
In 1990, John gained a Bachelors degree with honours in Applied Chemistry at Nottingham Trent University by part time study whilst working as an Analytical Chemist for Severn Trent Laboratories. After twelve years in this role, in 1996 he took the decision to leave full-time employment in order to take a Masters Degree at Loughborough University in Analytical Chemistry and Instrumentation which was achieved with Distinction. Following directly on from this he completed a PhD in Ion Mobility / Mass Spectrometry under the supervision of Professor Colin Creaser once again at Nottingham Trent. The subsequent two years were spent working as an Applications Chemist and Technical Trainer at Micromass (Waters), the mass spectrometry manufacturing company. A move into research followed and for the past five years John has been working in Cancer Studies at Manchester University in a proteomics-based mass spectrometry role. His work principally involves advanced method development on a number of mass spectrometry platforms.
Selected Publications
John R Griffiths and Richard D Unwin, "The Application of MRM-based Strategies to the Analysis of Post-Translational Modifications" in The Bioanalytical Discovery of Post Translational Modifications, Eds. J. Lill, Research Signpost, Kerala, (accepted 2008).
Siān H Leech, Caroline A Evans, Leila Shaw, Chi H Wong, Joanne Connolly, John R Griffiths, Anthony D. Whetton and Bernard M Corfe, Proteomic analysis of intermediate filaments reveals cytokeratin 8 is highly acetylated implications for colorectal epithelial homeostasis, Proteomics, 8, 279, (2008).
Arkadiusz Welman., John R. Griffiths, Anthony D. Whetton and Caroline Dive, Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells, Protein Science, 16, 2711, (2007).
John R. Griffiths, Richard D. Unwin, Caroline A. Evans, Siān H. Leech, Bernard M. Corfe and Anthony D. Whetton, The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues, J. Am. Soc. Mass Spectrom., 18, 1423, (2007).
Richard D. Unwin, John R. Griffiths, Michael K. Leverentz, Agnes Grallert, Iain M. Hagan and Anthony D. Whetton, Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity, Mol. Cell. Proteomics, 4, 1134, (2005).
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